Long-term outpatient cardiovascular outcomes following fertility therapy failure
| Outcome | Fertility therapy | Relative rate ratio* (95% CI) | ||||
|---|---|---|---|---|---|---|
| Failure n = 19 093 | Success n = 9349 | |||||
| No. | Rate† | No. | Rate† | Unadjusted | Adjusted‡ | |
| Any cardiovascular event | 1925 | 1.08 | 761 | 0.91 | 1.19 (1.11–1.27) | 1.21 (1.13–1.30) |
| Coronary ischemia | 392 | 0.22 | 175 | 0.21 | 1.05 (0.98–1.13) | 0.86 (0.80–0.93) |
| Heart failure | 352 | 0.20 | 132 | 0.16 | 1.25 (1.15–1.37) | 2.25 (2.06–2.46) |
| Venothromboembolism | 668 | 0.37 | 272 | 0.32 | 1.15 (1.07–1.25) | 1.08 (1.00–1.17) |
| Cerebrovascular events | 513 | 0.29 | 182 | 0.22 | 1.32 (1.22–1.44) | 1.25 (1.15–1.37) |
| Ischemic stroke/TIA | 468 | 0.26 | 156 | 0.19 | 1.41 (1.29–1.54) | 1.33 (1.22–1.46) |
| Hemorrhagic stroke | 45 | 0.025 | 26 | 0.031 | 0.81 (0.75–0.89) | 0.88 (0.80–0.96) |
Note: CI = confidence interval, TIA = transient ischemic attack.
↵* Rate ratios represent frequency among women following fertility therapy failure compared with those following successful fertility therapy.
↵† Absolute rates denote events per 100 patient-years of follow-up.
↵‡ Adjusted for age, calendar year, geographic residence, neighbourhood income quintile, prior health care visits, cardiovascular risk factors (e.g., hypertension, diabetes, hypercholesterolemia, smoking and obesity), history of ischemic heart disease, heart failure, atrial fibrillation, asthma, depression, neoplasm, prior live births, miscarriages and stillbirths, and number of fertility cycles.