Table 4:

Association between statin use and major hemorrhage

StatinNo. (%)OR (95% CI)Adjusted OR* (95% CI)
n = 1117
n = 4465
Atorvastatin, pravastatin, fluvastatin or rosuvastatin (ref)984 (88.1)4069 (91.1)1.001.00
Simvastatin or lovastatin133 (11.9)396 (8.9)1.39 (1.13–1.71)1.46 (1.17–1.82)
  • Note: CI = confidence interval, OR = odds ratio, ref = reference category.

  • * Adjusted for history of major hemorrhage, Charlson Comorbidity Index score, myocardial infarction, angina, congestive heart failure, chronic kidney disease, chronic liver disease, residence in long-term care facility, number of prescription drugs in previous year, medications (β-adrenergic receptor blockers, nitrates, clopidogrel, warfarin, nonsteroidal anti-inflammatory drugs, P-glycoprotein inhibitors, P-glycoprotein inducers, cytochrome P450 3A4 inhibitors), angiography and percutaneous coronary angioplasty.