Area under the receiver operating characteristic curve (AUC) for the basic and extended diagnostic prediction models, by data set
| Data set | AUC (95% CI) | Change in AUC | p value | |
|---|---|---|---|---|
| Basic model | Extended model* | |||
| Melbye et al.21 | 0.77 (0.66–0.89) | 0.88 (0.79–0.96) | 0.11 | 0.01 |
| Hopstaken et al.22 | 0.68 (0.59–0.78) | 0.86 (0.79–0.94) | 0.18 | < 0.001 |
| Flanders et al.28 | 0.92 (0.85–1.00) | 0.97 (0.94–1.00) | 0.05 | 0.2 |
| Graffelman et al.29 | 0.76 (0.65–0.86) | 0.78 (0.68–0.88) | 0.02 | 0.3 |
| Holm et al.30 | 0.78 (0.71–0.86) | 0.83 (0.76–0.90) | 0.05 | 0.02 |
| Rainer et al.7 | 0.75 (0.71–0.79) | 0.80 (0.76–0.83) | 0.05 | < 0.001 |
| Steurer et al.8 | 0.70 (0.65–0.75) | 0.85 (0.81–0.88) | 0.15 | < 0.001 |
| van Vugt et al.9 | 0.73 (0.68–0.77) | 0.79 (0.75–0.83) | 0.06 | < 0.001 |
Note: CI = confidence interval.
↵* Basic model plus C-reactive protein measurement.