Table 1:

Braak staging of Lewy body deposition10

StageSites affected by Lewy bodiesMajor symptoms
IDorsal motor nucleus of the vagus nerve and olfactory tractConstipation, anosmia
IILocus coeruleus and subcoeruleus complexSleep and mood dysfunction
IIISubstantia nigraMotor symptoms of Parkinson disease
IV–VICortical involvementDementia, psychosis