Multivariable logistic regression model used to derive the Canadian Syncope Risk Score
| Variable | β coefficient* | p value | Odds ratio* (95% CI) |
|---|---|---|---|
| Predisposition to vasovagal syncope† | −0.56 | 0.03 | 0.57 (0.33–0.98) |
| History of heart disease‡ | 0.52 | 0.007 | 1.69 (1.13–2.53) |
| Any systolic BP reading < 90 or > 180 mm Hg in emergency department§ | 0.76 | < 0.001 | 2.14 (1.43–3.21) |
| Elevated troponin (> 99th percentile of normal population) | 1.15 | < 0.001 | 3.19 (1.98–5.12) |
| Abnormal QRS axis (< −30° or > 110°) | 0.48 | 0.03 | 1.62 (1.01–2.62) |
| QRS duration > 130 ms | 0.64 | 0.01 | 1.89 (1.11–3.24) |
| Corrected QT interval > 480 ms | 0.90 | < 0.001 | 2.45 (1.54–3.92) |
| Emergency department diagnosis of vasovagal syncope | −0.98 | < 0.001 | 0.38 (0.22–0.66) |
| Emergency department diagnosis of cardiac syncope | 1.09 | < 0.001 | 2.96 (1.93–4.54) |
| Intercept | −3.86 | < 0.001 | – |
Hosmer–Lemeshow goodness-of-fit χ2 = 13.1, 7 degrees of freedom, p = 0.1.
Area under receiver operating characteristic curve (C statistic) = 0.88 (95% CI 0.85–0.90).
Optimism 0.015.
Optimism-corrected C statistic = 0.87 (95% CI 0.84–0.89).
Note: BP = blood pressure, CI = confidence interval, ECG = electrocardiogram.
↵* Shrinkage-corrected regression coefficients and odds ratios.
↵† Triggered by being in a warm crowded place, prolonged standing, fear, emotion or pain.
↵‡ Includes coronary or valvular heart disease, cardiomyopathy, congestive heart failure and non-sinus rhythm (ECG evidence during index visit or documented history of ventricular or atrial arrhythmias, or device implantation).
↵§ Includes BP readings from triage until disposition from emergency department.