Pregnancies during isotretinoin treatment and up to 42 weeks after the end of treatment, determined by high-sensitivity and high-specificity definitions of pregnancy
| Province | No. of patients | No. of courses | During isotretinoin treatment | Up to 42 wk after treatment | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pregnancies: high-specificity | Pregnancies: high-sensitivity | Pregnancies: high-specificity | Pregnancies: high-sensitivity | |||||||
| No. | No. per 1000 users | No. | No. per 1000 users | No. | No. per 1000 users | No. | No. per 1000 users | |||
| British Columbia | 37 285 | 64 541 | 106 | 2.8 | 212 | 5.7 | 912 | 24.5 | 1 581 | 42.4 |
| Saskatchewan | 10 890 | 20 591 | 18 | 1.7 | 50 | 4.6 | 96 | 8.8 | 236 | 21.7 |
| Manitoba | 6 741 | 10 314 | 19 | 2.8 | 24 | 3.6 | 150 | 22.3 | 181 | 26.9 |
| Ontario | 4 355 | 6 862 | 43 | 9.9 | 81 | 18.6 | 315 | 72.3 | 509 | 116.9 |
| Total or rate | 59 271 | 102 308 | 186 | 3.1 | 367 | 6.2 | 1 473 | 24.9 | 2 507 | 42.3 |