Table 2:

Association between sudden death and recent antibiotic use*

AntibioticNo. (%) of patientsOR (95% CI)
Cases
n = 328
Controls
n = 1171
UnadjustedAdjusted
TMP/SMX86 (26.2)189 (16.1)2.45 (1.67–3.61)2.46 (1.55–3.90)
Nitrofurantoin49 (14.9)202 (17.3)1.32 (0.86–2.02)1.70 (1.03–2.79)
Norfloxacin27 (8.2)162 (13.8)0.84 (0.51–0.39)0.86 (0.47–1.58)
Ciprofloxacin105 (32.0)289 (24.7)1.99 (1.38–2.87)1.55 (1.02–2.38)
Amoxicillin61 (18.6)329 (28.1)1.00 (ref)1.00 (ref)
  • Note: CI = confidence interval, OR = odds ratio, ref = reference group, TMP/SMX = trimethoprim–sulfamethoxazole.

  • * Antibiotic use in preceding 14 d.

  • Adjusted for disease risk index (covariates in Appendix 2, available at www.cmaj.ca/lookup/suppl/doi:10.1503/cmaj.140816/-/DC1) and duration of spironolactone use.