Table 2:

Results of the updated literature search, reference screening and reference classification

CharacteristicGuidelines topic and year of publicationTotal
Major depression in adults, 200815Obesity in childhood and adolescence, 200918Prostate cancer treatment, 200816Secondary prevention of stroke, 200917
References found during updated exhaustive literature search, no.11 2439 7633 34314 78739 136
First reference screening from all recommendations, no. (%)
Duplicate3 846 (34.2)2 445 (25.0)286 (8.6)1 582 (10.7)8 159 (20.8)
Excluded6 976 (62.0)6 981 (71.5)2 901 (86.8)12 940 (87.5)29 798 (76.1)
Included (pertinent references)260 (2.3)334 (3.4)102 (3.1)255 (1.7)951 (2.4)
New*161 (1.4)3 (0.0)54 (1.6)10 (0.1)228 (0.6)
Second reference screening from sample recommendations, no. (%)n = 192n = 292n = 106n = 78n = 668
Pertinent references73 (38.0)93 (31.8)22 (20.8)12 (15.4)200 (29.9)
Relevant references106 (55.2)167 (57.2)73 (68.9)53 (67.9)399 (59.7)
Key references13 (6.8)32 (11.0)11 (10.4)13 (16.7)69 (10.3)
Key references, type of study, no. (%)n = 13n = 32n = 11n = 13n = 69
Randomized controlled trial8 (61.5)23 (71.9)9 (81.8)4 (30.8)44 (63.8)
Systematic review5 (38.5)9 (28.1)2 (18.2)9 (69.2)25 (36.2)
Key references, recommendation change, no. (%)§
Population1 (7.7)4 (12.5)1 (7.7)6 (8.7)
Intervention12 (92.3)5 (15.6)2 (18.2)7 (53.8)26 (37.7)
Comparison2 (6.3)2 (18.2)1 (7.7)5 (7.2)
Outcome9 (69.2)2 (6.3)3 (27.3)14 (20.3)
Quality of the evidence11 (84.6)25 (78.1)5 (45.5)5 (38.5)46 (66.7)
Direction of the recommendation9 (69.2)9 (13.0)
Strength of the recommendation11 (84.6)14 (43.8)7 (63.6)6 (46.2)38 (55.1)
  • * References that may be related to new recommendations.

  • All relevant references were also pertinent.

  • All key references were also pertinent and relevant.

  • § One reference may change more than one issue.

  • Fourteen key references changed the quality of evidence.