Adjusted comparison of neonatal outcomes between baseline and 3 intervention years
| Outcome† | Comparison; adjusted OR (95% CI)* | ||
|---|---|---|---|
| Baseline to year 1 | Baseline to year 2 | Baseline to year 3 | |
| Composite | 0.87 (0.70 to 1.08) | 0.95 (0.76 to 1.18) | 0.63 (0.51 to 0.79) |
| GA 220 to 256 wk | 0.84 (0.51 to 1.39) | 0.99 (0.59 to 1.68) | 0.73 (0.44 to 1.20) |
| GA 260 to 286 wk | 0.89 (0.70 to 1.12) | 0.94 (0.74 to 1.19) | 0.62 (0.49 to 0.78) |
| Death | 0.88 (0.67 to 1.15) | 0.83(0.63 to 1.09) | 0.86 (0.65 to 1.13) |
| GA 220 to 256 wk | 0.86 (0.59 to 1.27) | 0.89 (0.60 to 1.30) | 0.86 (0.59 to 1.25) |
| GA 260 to 286 wk | 0.93 (0.59 to 1.44) | 0.74 (0.47 to 1.16) | 0.87 (0.56 to 1.38) |
| Bronchopulmonary dysplasia | 1.04 (0.83 to 1.44) | 1.10 (0.88 to 1.38) | 0.81 (0.64 to 1.01) |
| GA 220 to 256 wk | 1.47 (1.01 to 2.12) | 1.41 (0.97 to 2.06) | 1.12 (0.78 to 1.61) |
| GA 260 to 286 wk | 0.96 (0.75 to 1.24) | 1.04 (0.80 to 1.34) | 0.76 (0.59 to 0.99) |
| Severe neurologic injury | 0.96 (0.73 to 1.25) | 0.88 (0.67 to 1.15) | 0.91 (0.69 to 1.19) |
| GA 220 to 256 wk | 0.79 (0.57 to 1.11) | 0.71 (0.51 to 0.99) | 0.82 (0.59 to 1.14) |
| GA 260 to 286 wk | 1.08 (0.77 to 1.52) | 1.02 (0.72 to 1.44) | 0.95 (0.67 to 1.35) |
| Severe retinopathy of prematurity | 0.78 (0.60 to 1.03) | 0.88 (0.67 to 1.14) | 0.60 (0.45 to 0.79) |
| GA 220 to 256 wk | 0.72 (0.48 to 1.07) | 0.75 (0.50 to 1.12) | 0.59 (0.40 to 0.88) |
| GA 260 to 286 wk | 0.87 (0.58 to 1.33) | 1.08 (0.72 to 1.61) | 0.57 (0.36 to 0.92) |
| Necrotizing enterocolitis | 0.98 (0.70 to 1.37) | 0.83 (0.59 to 1.17) | 0.73 (0.52 to 0.98) |
| GA 220 to 256 wk | 0.86 (0.50 to 1.45) | 0.97 (0.57 to 1.64) | 0.77 (0.45 to 1.31) |
| GA 260 to 286 wk | 0.98 (0.70 to 1.37) | 0.83 (0.58 to 1.17) | 0.72 (0.50 to 1.04) |
| Nosocomial infection | 0.84 (0.64 to 1.08) | 0.79 (0.61 to 1.03) | 0.63 (0.48 to 0.82) |
| GA 220 to 256 wk | 0.95 (0.69 to 1.30) | 0.89 (0.64 to 1.22) | 0.85 (0.62 to 1.16) |
| GA 260 to 286 wk | 0.78 (0.58 to 1.07) | 0.75 (0.55 to 1.02) | 0.51 (0.37 to 0.71) |
Note: CI = confidence interval, GA = gestational age, OR = odds ratio.
↵* Adjusted ORs (and 95% CIs) based on hierarchical logistic regression models with random intercept and random site-intervention interaction, adjusted for sex, GA, small-for-GA status, Apgar score at 5 min and Score for Neonatal Acute Physiology, version II (SNAP-II score) > 20.
↵† For GA subgroups, the superscript 0 and 6 denotes number of days in addition to weeks of gestation.