Changes in diastolic function among patients who received placebo or G-CSF after myocardial infarction
| Variable | Time after treatment; group; mean ± SD* | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 6 mo | Change | |||||||
| Placebo n = 42 | G-CSF n = 42 | p value | Placebo n = 31 | G-CSF n = 34 | p value | Placebo | G-CSF | p value | |
| e′ lateral, cm/s | 8.3 ± 2.5 | 8.8 ± 1.4 | 0.5 | 8.3 ± 2.3 | 9.7 ± 2.4 | 0.02 | 0.0 ± 3.0 | −0.9 ± 2.6 | 0.2 |
| Deceleration time, s | 0.17 ± 0.04 | 0.17 ± 0.05 | 0.4 | 0.21 ± 0.05 | 0.22 ± 0.07 | 0.6 | −0.05 ± 0.06 | −0.05 ± 0.07 | 0.7 |
| E/A ratio | 1.2 ± 0.5 | 1.2 ± 0.5 | 0.4 | 1.2 ± 0.8 | 1.7 ± 1.3 | 0.2 | −0.1 ± 0.6 | −0.5 ± 1.2 | 0.3 |
| E/e′ ratio | 10.2 ± 3.0 | 8.8 ± 2.2 | 0.08 | 9.2 ± 3.1 | 7.7 ± 3.5 | 0.01 | 1.1 ± 2.8 | 1.2 ± 3.3 | 0.9 |
| Left atrial volume, mL | 43.1 ± 16.9 | 46.3 ± 14.8 | 0.2 | 44.3 ± 14.0 | 57.4 ± 23.5 | 0.04 | 1.1 ± 16.5 | 11.1 ± 23.2 | 0.06 |
| Grade 2 or 3, no. (%)of patients | 9 (29) | 12 (35) | 0.8 | 5 (16) | 12 (35) | 0.1 | NA | NA | NA |
Note: e′ lateral = peak early diastolic lateral mitral annular velocity, E/A ratio = ratio of peak early and late filling velocities, E/e′ ratio = ratio of E wave to e′ wave, G-CSF = granulocyte colony-stimulating factor, NA = not applicable, SD = standard deviation.
↵* Unless otherwise stated.