Table 4:

Clinical and laboratory features of latent autoimmune diabetes of adulthood6,30,33

Clinical considerationsLaboratory features
Age > 30 yrGAD and ICA antibodies present
Patients may be overweight, but typically leaner than those with type 2 diabetesInsulin antibodies often absent
Patients may have mild to moderate insulin resistance27Autoimmune markers may show subtle differences from those of childhood type 1 diabetes, but are more similar to antibodies seen in adult-onset type 1 diabetes29
Occurs in people of various ethnicities
Progression to insulin therapy slower than for patients with type 1 diabetes, but quicker than for those with type 2 diabetes
Avoid β-cell stressors such as secretagogues32
May be treated initially with oral antihyperglycemic agents, but insulin should be introduced early if glycemic control cannot be maintained
  • Note: GAD = glutamic acid decarboxylase, ICA = islet cell antibodies.