Risk of spontaneous abortion following exposure to nonsteroidal anti-inflammatory drugs, by defined daily dose: categorical time-varying multivariate Cox regression model
| No. of defined daily doses* | Spontaneous abortions % (no./total no.) | Adjusted hazard ratio† (95% CI) |
|---|---|---|
| 0 | 10.0 (6 251/62 432) | 1.00 (reference) |
| 1–2 | 5.6 (55/977) | 0.93 (0.77–1.13) |
| 3–9 | 10.5 (101/961) | 0.76 (0.54–1.07) |
| ≥ 10 | 9.2 (99/1 080) | 1.23 (0.94–1.62) |
Note: CI = confidence interval.
↵* Assumed average maintenance dose per day for a drug when it is used in adults for its main indication.
↵† Adjusted for maternal age, hypothyroidism, obesity, diabetes mellitus, hypercoagulation state, uterine disorders, presence of an intrauterine contraceptive device, history of recurrent abortions, in vitro fertilization used to conceive the current pregnancy, inflammatory diseases and ethnic group (Bedouin v. Jewish).