Association between neonatal outcomes among singleton liveborn infants (n = 11 293) and mother’s receipt of seasonal influenza vaccine during pregnancy
| Outcome | Maternal vaccination status; no. (%) of infants | Effect of vaccine (v. no vaccine) | ||
|---|---|---|---|---|
| No vaccine n = 9437* | Vaccine n = 1856* | Unadjusted OR (95% CI) | Adjusted OR† (95% CI) | |
| Preterm birth (< 37 wk) | 617 (6.5) | 92 (5.0) | 0.75 (0.60–0.93) | 0.75 (0.60–0.94) |
| Low birth weight (< 2500 g) | 461 (4.9) | 65 (3.5) | 0.71 (0.54–0.92) | 0.73 (0.56–0.95) |
| Low birth weight at term | 160 (1.7) | 26 (1.4) | 0.82 (0.54–1.25) | 0.85 (0.56–1.29) |
| Small-for-gestational age (< 10th percentile) | 749 (8.0) | 138 (7.5) | 0.93 (0.77–1.12) | 0.96 (0.79–1.16) |
| Composite neonatal morbidity variable‡ | 441 (4.7) | 95 (5.1) | 1.10 (0.88–1.38) | 1.06 (0.85–1.34) |
Note: CI = confidence interval, OR = odds ratio.
↵* Numbers exclude infants whose mothers had missing values for adjustment covariates in the model.
↵† Adjusted for maternal age, high-risk status, smoking during pregnancy, marital status, parity and location of residence.
↵‡ Includes neonatal death, asphyxia, sepsis, low Apgar score at 5 min, moderate or severe respiratory distress syndrome, intraventricular hemorrhage and acute necrotizing enterecolitis.