Adjusted rates of progression to kidney failure per 1000 person-years, by First Nations status, albuminuria level and estimated glomerular filtration rate
| Albuminuria | Estimated GFR, mL/min per 1.73 m2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Non–First Nations participants | First Nations participants | |||||||||
| ≥ 90.0 | 60.0–89.9 | 45.0–59.9 | 30.0–44.9 | 15.0–29.9 | ≥ 90.0 | 60.0–89.9 | 45.0–59.9 | 30.0–44.9 | 15.0–29.9 | |
| Normal | ||||||||||
| No. of events | 969 | 1207 | 465 | 289 | 163 | 65 | 23 | 5 | 3 | 0 |
| No. of participants | 559 096 | 383 776 | 41 144 | 11 337 | 2450 | 14 524 | 3959 | 281 | 54 | 15 |
| Adjusted* rate (95% CI) | 0.48 (0.44–0.53) | 0.46 (0.42–0.51) | 0.76 (0.66–0.87) | 1.30 (1.11–1.51) | 3.44 (2.92–4.05) | 0.97 (0.63–1.49) | 0.84 (0.52–1.38) | 1.56 (0.79–3.05) | 2.75 (1.32–5.72) | 9.15 (4.71–17.79) |
| Mild | ||||||||||
| No. of events | 219 | 385 | 176 | 186 | 174 | 31 | 15 | 0 | 3 | 4 |
| No. of participants | 38093 | 28758 | 6121 | 2886 | 1196 | 2284 | 646 | 75 | 40 | 16 |
| Adjusted* rate (95% CI) | 1.33 (1.16–1.53) | 1.27 (1.1–1.46) | 2.08 (1.75–2.46) | 3.56 (2.98–4.25) | 9.44 (7.85–11.34) | 2.18 (1.23–3.87) | 1.90 (1.03–3.51) | 3.50 (1.66–7.37) | 6.18 (2.82–13.58) | 20.57 (9.85–42.94) |
| Heavy | ||||||||||
| No. of events | 138 | 262 | 196 | 267 | 359 | 11 | 19 | 10 | 15 | 25 |
| No. of participants | 4867 | 4484 | 1705 | 1347 | 892 | 344 | 156 | 39 | 34 | 34 |
| Adjusted* rate (95% CI) | 4.29 (3.69–4.97) | 4.08 (3.51–4.74) | 6.68 (5.64–7.93) | 11.46 (9.63–13.64) | 30.38 (25.57–36.10) | 7.35 (4.27–12.65) | 6.40 (3.62–11.31) | 11.79 (5.92–23.49) | 20.86 (10.48–41.50) | 69.37 (38.91–123.70) |
| Not measured | ||||||||||
| No. of events | 1258 | 1956 | 916 | 762 | 643 | 187 | 90 | 38 | 24 | 37 |
| No. of participants | 356 704 | 262793 | 39 766 | 15 875 | 4865 | 20 337 | 5031 | 531 | 182 | 87 |
| Adjusted* rate (95% CI) | 0.89 (0.82–0.98) | 0.85 (0.77–0.93) | 1.39 (1.22–1.59) | 2.39 (2.06–2.76) | 6.33 (5.41–7.40) | 1.98 (1.52–2.57) | 1.72 (1.20–2.47) | 3.17 (1.80–5.60) | 5.61 (3.00–10.51) | 18.67 (10.77–32.36) |
Note: CI = confidence interval, GFR = glomerular filtration rate.
↵* Adjusted for age (categories: 18 to < 40 yr, 40 to < 60 yr, 60 to < 75 yr and ≥ 75 yr), sex, diabetes, hypertension, location of residence, income quintile, specialist care and the comorbidities listed in Table 1. Interactions included in the model are ethnicity and albuminuria, and ethnicity and GFR.