Table 2:

Rates of hypoglycemia and nocturnal plasma glucose concentrations among 15 patients with type 1 diabetes during each intervention

OutcomeIntervention, no. (%)p value*
Dual-hormone closed-loop delivery
n = 15
Continuous subcutaneous insulin infusion
n = 15
Patients with at least 1 hypoglycemic event1 (7)8 (53)0.02
Patients with at least 1 nocturnal hypoglycemic event0 (0)5 (33)0.07
Patients with at least 1 exercise-induced hypoglycemic event§1 (7)2 (13)1.0
Nocturnal plasma glucose measurementsn = 363n = 367
 < 4.0 mmol/L2 (0.5)45 (12.3)
 < 3.3 mmol/L0 (0.0)13 (3.5)
 < 3.0 mmol/L0 (0.0)9 (2.5)
  • * McNemar test.

  • Defined as at least 1 measurement of plasma glucose concentration < 3.0 mmol/L, which was treated by oral carbohydrate.

  • Between the hours of 2300 and 0700.

  • § From start of exercise to 1920.

  • Measurements were taken at 20-min intervals.