Variable | Cohort entry | Study end | ||
---|---|---|---|---|
PCOS* | Matched controls | PCOS* | Matched controls | |
Medication use, % of women | ||||
ACE inhibitor or ARB | 2.18 | 2.57 | 5.06 | 5.10 |
Beta blocker | 3.42 | 3.52 | 7.95 | 6.80 |
Benzodiazepine | 8.93 | 8.06 | 20.77 | 16.95 |
Calcium-channel blocker | 0.92 | 1.06 | 2.51 | 2.18 |
Diabetes medications | 20.31 | 20.65 | 42.88 | 21.55 |
SSRI or tricyclic antidepressant | 17.09 | 17.32 | 31.76 | 28.88 |
Statin or fibrate | 2.45 | 2.79 | 5.79 | 5.23 |
Comorbidities, % of women | ||||
Acne | 11.04 | 10.92 | 24.15 | 19.65 |
Asthma | 6.93 | 6.92 | 15.32 | 12.82 |
COPD | 3.34 | 3.45 | 11.45 | 9.29 |
Diabetes | 6.70 | 8.31 | 14.87 | 12.23 |
Dysmenorrhea | 5.79 | 5.71 | 14.23 | 10.95 |
Endometriosis | 2.71 | 2.82 | 7.42 | 4.88 |
Hyperlipidemia | 10.47 | 10.91 | 27.10 | 20.15 |
Hypertension | 7.82 | 8.40 | 18.70 | 14.75 |
Hypothyroid | 8.23 | 8.32 | 17.23 | 12.67 |
Ovarian inflammation | 1.74 | 1.83 | 5.72 | 3.84 |
Vaginal inflammation | 12.56 | 12.52 | 31.22 | 27.64 |
Uterine leiomyoma | 2.05 | 2.03 | 5.96 | 4.65 |
Irregular menstrual cycle | 40.04 | 40.06 | 72.07 | 54.15 |
Migraine | 5.53 | 5.67 | 15.10 | 12.33 |
Mood or anxiety disorder | 15.96 | 16.26 | 34.09 | 29.65 |
Obesity | 13.35 | 13.32 | 33.11 | 21.04 |
Peptic ulcer disease | 0.40 | 0.42 | 1.32 | 1.03 |
Premenstrual tension syndrome (PMS or PMDD) | 1.42 | 1.34 | 4.12 | 2.97 |
Sleep disorder | 0.82 | 0.88 | 3.26 | 1.98 |
Smoking | 2.57 | 2.71 | 7.31 | 6.85 |
Note: ACE = angiotensin-converting enzyme, ARB = angiotensin-receptor blocker, COPD = chronic obstructive pulmonary disorder, PCOS = polycystic ovary syndrome, PMDD = premenstrual dysphoric disorder, PMS = premenstrual syndrome, SSRI = selective serotonin reuptake inhibitor.
↵* Defined as a claim for PCOS (International Classification of Disease, 9th Revision [Clinical Modification (ICD-9-CM)] 256.4).