Table 2:

Changes in spasticity, pain and cognitive performance, by treatment

Performance measurePlaceboCannabisMean differenceEffect
Before treatmentAfter treatmentBefore treatmentAfter treatmentCannabisPlacebo
Spasticity, modified Ashworth score, mean (95% CI)*8.92 (8.03 to 9.79)8.71 (7.57 to 9.71)9.13 (8.21 to 10.07)6.18 (5.13 to 7.21)2.95 (2.49 to 3.38)0.21 (−0.09 to 0.51)2.74 (2.20 to 3.14)
Pain, visual analogue score, mean (95% CI)14.51 (9.16 to 21.75)11.52 (7.21 to 18.32)16.61 (10.79 to 24.93)8.34 (4.89 to 14.39)8.27 (4.51 to 13.49)2.99 (0.04 to 6.55)5.28 (2.48 to 10.01)
Physical performance, timed walk, s, mean (95% CI)11.68 (8.87 to 16.41)11.70 (8.81 to 16.98)11.66 (8.90 to 16.69)12.89 (9.55 to 17.94)1.23 (0.33 to 2.63)0.03 (−0.95 to 1.63)1.20 (0.15 to 4.31)
Cognitive function, PASAT score, mean (95% CI)§138.08 (123.76 to 149.74)138.43 (123.37 to 150.38)140.78 (127.31 to 151.52)132.46 (116.38 to 144.07)8.32 (4.95 to 14.16)−0.35 (−2.92 to 2.47)8.67 (4.10 to 14.31)
  • Note: CI = confidence interval, PASAT = paced auditory serial addition test.

  • * Scores range from 0 to 24, with higher scores suggesting greater spasticity.

  • Scores range from 0 to 100, with higher scores suggesting more severe pain.

  • Times range from 0 to 66 s, with higher scores suggesting a slower pace.

  • § Scores range from 0 to 196, with higher scores suggesting better cognitive performance.