Table 2:

Relative risk of second primary cancer after first cancer in Danish population, 1980–2007*

Type/site of first cancerHodgkin diseaseSmall intestineNon-Hodgkin lymphomaThyroidSarcomaTestisMultiple myelomaEsophagusLarynxLiverBrainKidneyPharynxUterusStomachLeukemiaOvaryPancreasMelanomaUrinaryCervixProstateBreastColonLungSkinOther
Hodgkin disease
 HR2.001.530.75
 95% CI low0.190.120.09
 95% CI high21.518.96.08
Small intestine
 HR5.701.362.166.411.802.471.620.522.301.252.131.993.880.540.801.062.241.260.862.66
 95% CI low0.560.160.262.330.410.930.370.070.790.380.830.702.010.070.380.521.490.750.520.92
 95% CI high57.611.317.717.67.946.537.023.876.674.065.475.707.464.061.722.193.362.101.437.70
Non-Hodgkin lymphoma
 HR1.234.002.031.670.764.031.190.852.101.411.080.371.520.641.061.551.981.572.54
 95% CI low0.270.970.430.360.101.500.140.110.780.420.240.050.330.290.520.871.181.030.83
 95% CI high5.6516.59.557.765.9410.89.836.745.624.774.802.727.061.372.152.743.322.407.76
Thyroid
 HR1.395.652.222.491.680.311.442.872.081.351.941.971.340.551.630.791.231.171.301.230.73
 95% CI low0.172.160.840.930.570.040.601.541.010.711.041.040.720.200.980.410.910.810.920.930.26
 95% CI high11.514.85.866.614.942.253.445.344.302.573.633.722.471.502.711.491.671.711.831.632.01
Sarcoma
 HR4.721.281.3617.82.602.541.760.271.102.021.641.230.750.641.991.401.271.810.430.240.931.461.381.231.72
 95% CI low1.220.450.3110.50.861.290.690.040.481.050.840.590.270.261.130.700.661.090.190.060.641.061.040.921.39
 95% CI high18.23.665.9530.47.845.024.481.982.553.883.202.562.061.583.522.822.442.990.980.991.352.021.841.642.12
Testis
 HR8.761.792.522.532.310.542.270.811.991.332.161.043.721.871.421.392.111.221.781.251.161.553.93
 95% CI low0.790.640.631.271.450.131.200.320.970.741.220.572.271.080.790.881.370.880.180.910.871.242.37
 95% CI high96.85.0210.15.043.692.294.302.054.082.393.851.876.103.242.562.213.251.7017.11.701.561.946.52
Multiple myeloma
 HR1.664.592.202.690.411.271.111.402.611.261.631.741.460.920.672.431.201.950.830.730.811.081.581.09
 95% CI low0.371.420.970.310.060.500.560.601.510.650.891.000.840.400.331.540.730.740.580.480.600.831.290.57
 95% CI high7.3714.84.9723.23.023.212.213.284.502.443.013.002.562.121.363.841.995.141.181.111.091.411.932.08
Esophagus
 HR5.915.101.322.821.390.470.767.111.290.540.931.150.710.890.572.100.950.831.420.760.73
 95% CI low1.491.100.311.160.500.060.184.270.300.130.340.280.220.280.210.480.570.510.970.480.17
 95% CI high23.423.65.636.863.903.503.1611.85.522.212.554.792.282.851.579.231.581.362.081.203.03
Larynx
 HR1.732.380.671.754.277.331.371.064.750.891.041.051.421.620.851.722.070.771.101.303.421.461.20
 95% CI low0.661.190.160.963.095.210.870.683.750.380.700.680.771.130.491.341.020.630.791.103.071.270.77
 95% CI high4.524.782.823.195.9110.312.141.656.032.071.561.602.632.331.482.204.210.951.541.543.801.681.85
Liver
 HR12.52.073.461.735.690.621.721.301.982.342.150.321.351.293.5610.20.310.680.570.901.131.460.68
 95% CI low3.820.280.770.400.660.080.530.310.601.120.940.040.590.521.837.480.040.250.290.520.741.000.43
 95% CI high40.915.315.67.5048.74.495.555.446.474.904.932.313.093.206.9314.02.211.861.111.581.722.131.06
Brain
 HR20.72.811.972.363.211.310.731.300.791.424.322.060.671.101.192.220.862.800.801.041.210.781.191.031.341.67
 95% CI low2.820.640.840.831.620.390.230.570.250.692.531.200.270.530.611.320.381.870.420.530.840.530.890.771.070.87
 95% CI high15212.44.636.746.374.352.342.972.512.957.363.531.632.242.343.751.954.201.502.071.721.131.591.391.673.20
Kidney
 HR0.672.362.282.721.091.091.351.890.701.170.681.020.821.261.171.680.341.551.181.051.461.090.97
 95% CI low0.091.191.011.460.550.590.701.150.280.720.350.640.440.840.751.250.111.270.920.861.240.920.57
 95% CI high5.024.665.165.092.152.022.593.101.721.911.341.631.501.881.832.251.071.891.521.291.731.291.67
Pharynx
 HR6.690.792.491.331.111.310.925.474.471.461.030.9715.40.581.431.090.961.571.221.190.820.811.271.062.522.020.84
 95% CI low1.090.191.500.600.570.380.544.313.391.050.630.6412.60.311.060.780.591.180.860.930.410.681.030.912.281.830.56
 95% CI high41.03.384.132.942.144.441.566.935.892.051.681.4818.91.071.921.531.562.091.731.531.640.971.571.242.782.241.26
Uterus
 HR1.150.671.511.920.670.891.050.951.610.840.140.920.471.120.961.190.481.181.050.851.140.78
 95% CI low0.540.350.871.190.380.460.750.651.210.560.070.680.350.880.730.900.331.080.940.731.040.56
 95% CI high2.431.292.613.101.181.721.481.402.151.260.271.250.631.431.271.560.701.301.180.971.261.08
Stomach
 HR2.001.730.531.791.300.721.151.110.932.120.921.431.642.170.881.081.120.851.031.211.081.100.31
 95% CI low0.700.700.070.850.170.320.610.620.431.390.500.810.991.550.460.730.520.650.760.990.880.910.11
 95% CI high5.694.303.863.7410.01.642.191.991.993.211.682.512.743.031.661.612.421.111.391.481.321.320.82
Leukemia
 HR8.361.625.046.791.832.370.461.270.952.332.162.010.881.050.411.111.292.051.041.410.820.961.161.702.941.61
 95% CI low1.990.573.323.621.031.030.200.750.591.531.521.390.500.690.170.670.901.490.750.820.660.750.981.472.671.13
 95% CI high35.14.617.6512.73.245.451.042.161.543.573.072.911.551.590.991.821.832.831.452.421.021.221.361.963.242.30
Ovary
 HR0.701.051.171.730.741.922.501.070.731.131.290.811.631.071.081.210.841.340.651.151.230.910.991.04
 95% CI low0.170.450.460.980.361.071.310.650.370.680.790.581.100.690.740.850.560.900.431.011.060.750.850.67
 95% CI high2.922.422.953.041.513.434.801.751.431.862.101.122.411.651.571.731.262.000.981.301.441.111.151.61
Pancreas
 HR12.53.481.422.881.941.354.800.302.300.741.110.822.651.180.800.380.640.970.710.830.86
 95% CI low5.430.830.190.340.700.422.870.041.140.230.510.331.270.370.250.120.340.660.440.560.27
 95% CI high28.614.610.924.55.374.418.022.174.642.352.412.015.563.772.571.181.201.421.121.222.74
Melanoma
 HR1.401.171.272.350.581.410.910.830.711.791.190.771.021.411.480.921.121.930.760.881.221.091.030.932.710.93
 95% CI low0.650.740.681.640.210.970.570.500.471.310.880.540.781.081.150.700.851.470.580.661.050.960.910.822.530.66
 95% CI high3.041.862.383.361.642.051.461.381.092.451.621.101.331.841.911.221.482.541.001.171.411.221.161.062.911.30
Urinary
 HR2.191.430.870.311.840.690.501.370.851.052.231.260.771.121.061.630.940.775.721.431.301.051.820.921.57
 95% CI low0.250.650.440.081.180.160.280.960.580.671.750.930.450.850.801.050.700.534.970.761.160.831.660.821.21
 95% CI high19.43.171.731.282.882.900.891.941.231.652.841.701.331.481.412.511.251.116.582.691.451.322.001.032.04
Cervix
 HR0.610.721.271.381.731.521.371.090.941.590.721.201.291.511.381.951.201.071.392.001.082.78
 95% CI low0.080.290.780.941.120.970.960.800.651.210.570.850.971.301.071.511.050.991.241.810.992.27
 95% CI high4.911.832.072.012.672.371.971.491.362.090.901.681.711.761.792.521.371.151.572.201.193.40
Prostate
 HR0.570.790.850.491.101.560.760.780.820.490.651.080.840.720.870.800.920.850.011.120.830.600.930.53
 95% CI low0.070.420.550.200.770.820.570.590.610.360.450.870.660.590.710.660.730.740.000.580.760.540.860.40
 95% CI high4.391.471.311.211.572.971.031.021.090.660.931.331.060.881.050.981.170.980.022.160.910.650.990.69
Breast
 HR2.261.151.041.061.500.941.060.770.650.880.891.021.221.281.061.120.891.090.880.721.031.400.970.971.140.57
 95% CI low0.730.760.780.771.170.750.830.560.520.720.740.851.111.090.911.010.770.960.740.620.601.320.910.911.090.47
 95% CI high7.071.731.371.451.911.181.361.060.801.091.071.221.341.491.231.231.021.241.030.831.771.471.031.041.200.69
Colon
 HR3.422.760.911.620.910.900.830.940.930.800.781.420.941.040.880.811.030.900.920.910.820.961.031.830.881.010.52
 95% CI low1.242.040.651.150.670.410.660.750.730.670.611.220.790.880.750.680.870.780.780.800.630.890.951.720.820.950.42
 95% CI high9.463.731.282.271.231.951.051.161.190.970.991.661.131.231.020.951.221.041.091.021.071.041.111.950.941.060.64
Lung
 HR5.651.771.293.371.481.860.931.582.191.140.912.761.530.320.871.241.061.230.881.361.350.951.020.840.960.900.78
 95% CI low1.250.860.732.120.940.800.611.161.670.840.612.261.170.170.650.950.730.970.631.120.880.820.860.740.820.800.54
 95% CI high25.53.672.265.352.324.331.432.152.871.541.353.372.000.601.151.611.531.561.231.652.071.091.200.961.121.001.11
Skin
 HR1.671.121.501.091.300.870.980.921.300.981.071.061.570.990.951.300.940.952.780.860.820.981.100.971.111.921.03
 95% CI low0.780.851.260.841.100.560.850.801.130.870.930.951.430.880.861.190.840.872.580.790.700.931.050.931.061.850.93
 95% CI high3.571.481.781.431.541.371.131.061.491.091.231.191.731.111.051.421.051.042.990.930.971.031.161.011.151.991.14
Other
 HR6.783.532.141.752.931.191.442.430.870.821.301.410.671.704.821.050.801.532.221.241.210.951.621.296.11
 95% CI low0.601.441.090.611.730.280.791.440.470.400.800.880.361.153.740.670.481.121.530.990.970.771.371.114.37
 95% CI high76.78.634.165.054.975.182.614.081.601.682.122.271.222.506.201.661.362.093.221.541.501.171.911.508.55
  • Note: CI = confidence interval, HR = hazard ratio.

  • * Hazard ratios were calculated in 1:5 matched nested studies; see Methods for details. Values in bold were significant (p < 0.05) after Bonferroni correction for mulitple comparisons.

  • These sex-specific estimates do not exist.