Table 1:

Children’s Oncology Group Long-Term Follow-Up Guidelines, version 5.0 (10)

Breast cancer	Colorectal cancer	Cardiomyopathy
Therapeutic exposure Any level of radiation exposure to the chest, axilla, or TBI Surveillance^* Mammography — Yearly, beginning at age 25 yr or 8 yr post-radiation, whichever occurs last Breast MRI — Yearly, as an adjunct to mammography, beginning at age 25 yr or 8 yr post-radiation, whichever occurs last	Therapeutic exposure Any level of radiation exposure to the abdomen, pelvis, spine (lumbar, sacral, whole), TBI Surveillance^* Multitarget stool DNA test — performed every 3 yr, beginning at age 30 yr or 5 yr after radiation, whichever occurs last. Positive result should be followed up with a timely colonoscopy Colonoscopy — Performed every 5 yr, beginning at age 30 yr or 5 yr after radiation, whichever occurs last.	Therapeutic exposure Anthracycline chemotherapy or radiation to a field that involves the heart Surveillance^* Echocardiogram (or comparable imaging to evaluate cardiac function) starting at the completion of cancer therapy^† Anthracycline dose = none If radiation dose is < 15 Gy or none, then the recommended frequency is “no surveillance” If radiation dose is ≥ 15 to < 35 Gy, then the recommended frequency is every 5 yr If radiation dose is ≥ 35 Gy, then the recommended frequency is every 2 yr. Anthracycline dose ≤ 250 mg/m² If radiation dose is < 15 Gy or none, then the recommended frequency is every 5 yr If radiation dose is ≥ 15 Gy, then the recommended frequency is every 2 yr. Anthracycline dose is ≥ 250 mg/m² If radiation dose is “any or none,” then the recommended frequency is every 2 yr

Note: MRI = magnetic resonance imaging, TBI = total body irradiation.
↵* Recommendations as per version 5.0 — October 2018. (10)
↵† Although echocardiographic screening is recommended to start during childhood, for the present analysis we have focused on screening that occurs once survivors become adults at age 18 years.