Table 4:

Adjusted odds ratios for intracranial tumours, leukemia and lymphomas related to the cumulative organ-specific dose from computed tomography scans, estimated using radiation dosimetry from Gao and colleagues (40)

Percentile of cumulative organ dose (absolute dose in mGy)No. of patients*No. of controls*Adjusted OR (95% CI)
Intracranial tumours
 No exposure1
 Brain dose 20th percentile (0.1 to 31.1)7581.19 (0.54–2.62)
 Brain dose 21st to 40th percentile (31.2 to 32.2)3600.51 (0.16–1.64)
 Brain dose 41st to 60th percentile (32.3 to 43.0)< 3550.36 (0.09–1.48)
 Brain dose 61st to 80th percentile (43.1 to 64.0)7381.97 (0.87–4.46)
 Brain dose 81st to 100th percentile (> 64.0)14393.61 (1.93–6.75)
 Brain dose 99th to 100th percentile (> 139.8)5315.49 (3.68–65.27)
Leukemia
 No exposure1
 RBM dose 20th percentile (0.1 to 9.0)171031.64 (0.98–2.75)
 RBM dose 21st to 40th percentile (9.1 to 11.2)3730.41 (0.13–1.31)
 RBM dose 41st to 60th percentile (11.3 to 15.3)4960.42 (0.15–1.14)
 RBM dose 61st to 80th percentile (15.4 to 20.0)5640.78 (0.31–1.95)
 RBM dose 81st to 100th percentile (> 20.0)7780.89 (0.41–1.94)
 RBM dose 99th to 100th percentile (> 51.9)365.38 (1.27–22.8)
Non-Hodgkin lymphoma
 No exposure1
 RBM dose 20th percentile (0.1 to 9.0)6371.62 (0.68–3.86)
 RBM dose 21st to 40th percentile (9.1 to 11.2)4221.87 (0.64–5.47)
 RBM dose 41st to 60th percentile (11.3 to 15.3)4331.23 (0.43–3.5)
 RBM dose 61st to 80th percentile (15.4 to 20.0)< 3360.28 (0.04–2.03)
 RBM dose 81st to 100th percentile (> 20.0)4361.11 (0.39–3.13)
 RBM dose 99th to 100th percentile (> 51.9)< 336.74 (1.12–40.35)
Hodgkin lymphoma
 No exposure1
 RBM dose 20th percentile (0.1 to 9.0)< 3220.45 (0.06–3.32)
 RBM dose 21st to 40th percentile (9.1 to 11.2)08NA
 RBM dose 41st to 60th percentile (11.3 to 15.3)< 3250.83 (0.2–3.5)
 RBM dose 61st to 80th percentile (15.4 to 20.0)3291.01 (0.31–3.32)
 RBM dose 81st to 100th percentile (> 20.0)020NA
 RBM dose 99th to 100th percentile (> 51.9)0< 3NA
  • Note: CI = confidence interval, mGy = milligray, NA = not applicable, OR = odds ratio, RBM = red bone marrow.

  • * National Health Insurance Research Database policy on protecting confidentiality requires suppression of cells < 3.

  • Adjusted by the year of cohort entry, annual family income (both as linear variables) and urbanization level (as a categorical variable).

  • Sensitivity analysis.