Table 1:

Characteristics of included randomized controlled trials

InterventionComparatorStudyYearRegistrationCountryAge, yr, meanSex, male, %No. of patients
TotalDiedHosp.MV
AzvudineStandard careRen542020ChiCTR2000029853China5260200NRNR
Emtricitabine–tenofovirStandard careParienti532021NCT04685512France45.2543.336003NR
Emtricitabine–tenofovirTenofovir, placeboArruda302021NCT04712357Brazil38.0435.4150NR5NR
Emtricitabine–tenofovirPlaceboGaitan-Duarte402021NCT04359095Colombia55.3967.6132419NRNR
FavipiravirStandard careBalykova312020NCT04542694Russia47.33NR390NR0
FavipiravirStandard careBalykova322020NRRussia49.6848.542060NR0
FavipiravirStandard careRuzhentsova562020NCT04501783Russia41.847.02168NR51
FavipiravirStandard careIvashchenko442020NCT04434248Russia50.7350402NR2
FavipiravirPlaceboShinkai582021JapicCTI-205238Japan45.3466.671560NR14
FavipiravirStandard careUdwadia592020CTRI/2020/05/025114India43.2973.471501NR14
FavipiravirUmifenovirChen362020ChiCTR2000030254ChinaNR46.612400NRNR
FavipiravirFavipiravirDoi382020jRCTs041190120Japan5061.3689NRNRNR
FavipiravirStandard careZhao652021NCT04333589China55.745.45550NRNR
Lopinavir–ritonavirStandard careAder572021NCT04315948France, Luxembourg6371.730013NR16
Lopinavir–ritonavirUmifenovir, placeboLi472020NCT04252885China49.446.51690NRNR
Lopinavir–ritonavirStandard careWang612020NRChinaNR38.360NRNRNR
MolnupiravirPlaceboBernal352021NCT04575597Argentina, Brazil, Canada, Chile, Colombia, Egypt, France, Germany, Guatemala, Israel, Italy, Japan, Mexico, Philippines, Poland, Russia, South Africa, Spain, Sweden, Taiwan, Ukraine, United Kingdom, United States44.8548.7114331411624
MolnupiravirPlaceboFischer392021NCT04405570United States40.0948.518514NR
MolnupiravirStandard careKhoo462021NCT04746183United Kingdom5627.7880NRNR
Nirmatrelvir–ritonavirPlaceboEPIC-SR3,682021NCT05011513North America, South America, Europe, Africa, AsiaNRNR854013NR
Nirmatrelvir–ritonavirPlaceboEPIC-HR (Hammond)672021NCT04960202Argentina, Brazil, Bulgaria, Colombia, Czechia, Hungary, India, Japan, Korea, Malaysia, Mexico, Peru, Puerto Rico, Poland, Russia, South Africa, Spain, Taiwan, Thailand, Turkey, Ukraine, United StatesNRNR22461276NR
NovaferonLopinavir–ritonavirZheng662020ChiCTR2000029496China46.7347.1960NRNRNR
RemdesivirPlaceboBeigel342020NCT04280705Denmark, Greece, Germany, Japan, Korea, Mexico, Spain, Singapore, United Kingdom, United States58.964.4110626NR5
RemdesivirStandard careAli292022NCT04330690Canada65.5159.8128212NR6
RemdesivirPlaceboGottlieb422021NCT04501952, EudraCT
Number 2020–003510–12
Denmark, Spain, United Kingdom, United States50.552.14584023NR
RemdesivirStandard careBarratt-Due332021NCT04321616Norway59.865.7594NRNRNR
RemdesivirStandard careCriner372020NCT04252664China57613848NRNR
RemdesivirStandard careOgbuagu512021NCT04252664ChinaNRNR1005NRNRNR
RemdesivirStandard carePan522020ISRCTN83971151, NCT04315948Albania, Argentina, Austria, Belgium, Brazil, Canada, Colombia, Egypt, Finland, France, Honduras, India, Indonesia, Iran, Ireland, Italy, Kuwait, Lebanon, Lithuania, Luxembourg, Macedonia, Malaysia, Norway, Pakistan, Peru, Phillippines, Saudi Arabia, South Africa, Spain, SwitzerlandNR62.94547524NRNR
RemdesivirPlaceboWang602020NCT04257656China6559.3223732NRNR
ResveratrolPlaceboMcCreary482021NCT04400890United States5640.95105040
Ribavirin, lopinavir–ritonavir–ribavirinLopinavir–ritonavirHuang432020ChiCTR2000029387China42.545.54690NRNR
Ribavirin–sofosbuvir–daclatasvirStandard careKasgari452020IRCT20200328046886N1Iran52.537.5483NR4
Sofosbuvir–daclatasvirStandard careRoozbeh552020IRCT20200403046926N1Iran4347.2760NR5NR
Sofosbuvir–daclatasvirPlaceboMobarak492021IRCT20200624047908N1Iran5854.021083128NR30
Sofosbuvir–daclatasvirLopinavir–ritonavirYadollahzadeh622021IRCT20200328046885N1Iran57.5644.641125NRNR
Sofosbuvir–daclatasvirStandard careYakoot632020DRKS00022203Egypt49.0142.7894NRNR
Sofosbuvir–ledipasvirStandard careKhalili502020IRCT20100228003449N29Iran62.23NR906NR7
TriazavirinPlaceboWu282020ChiCTR20000300001China5850521NRNR
UmifenovirStandard careGhaderkhani412020IR.TUMS.VCR. REC.1399.204, 04.13.2020Iran44.3860.3856NRNRNR
UmifenovirStandard careYethindra642020NRKyrgyzstan36.560300NRNR
  • Note: Hosp. = admitted to hospital, MV = mechanical ventilation, NR = not reported.