RT Journal Article
SR Electronic
T1 Plasma lipids and lipoprotein patterns in angiographically graded atherosclerosis of the legs and in coronary heart disease
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 1245
OP 1250
VO 116
IS 11
A1 J. Davignon
A1 S. Lussier-Cacan
A1 M. Ortin-George
A1 M. Lelievre
A1 C. Bertagna
A1 A. Gattereau
A1 A. Fontaine
YR 1977
UL http://www.cmaj.ca/content/116/11/1245.abstract
AB The prevalence and type of plasma lipoprotein abnormalities were determined in 114 French-Canadian patients with angiographically proven peripheral vascular disease (PVD). The severity of atherosclerosis was positively correlated with plasma triglyceride concentration, especially in the younger patients (r = 0.29, P less than 0.05), and (not significantly) with plasma cholesterol concentration. Of the risk factors believed to predispose individuals to atherosclerosis, cigarette smoking was the most frequently found in the PVD patients (72.8%), especially among the men. Combination of two or more risk factors was the rule. Findings were compared with those in 114 patients who had undergone coronary angiography for suspected coronary heart disease (CHD). The CHD patients were, on average, younger by 10 years. Hyperlipidemia was present in 58.8% of CHD patients, compared with 43.9% of PVD patients. A far higher proportion of CHD patients showed the type II plasma lipoprotein pattern (24.6% v. 7.9%), although the type IV pattern was more common in both groups (31.6% and 28.9%, respectively). A high proportion of all patients (56.1% with PVD and 41.2% with CHD) showed a normal lipoprotein pattern on paper electrophoresis.