RT Journal Article
SR Electronic
T1 [Laparotomy in Hodgkin's disease: significance of splenic involvement]
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 115
OP 118
VO 131
IS 2
A1 E. Tawil
A1 J. P. Mercier
YR 1984
UL http://www.cmaj.ca/content/131/2/115.abstract
AB We retrospectively reviewed 224 cases of Hodgkin's disease, in 120 of which staging laparotomy was performed. The surgical findings in cases of clinical stage I or II disease with supradiaphragmatic presentation or clinical stage III disease did not influence the treatment plans. Of the 64 patients with positive results of laparotomy (splenic or lymph node involvement or both) 51 had splenic involvement; their 5-year survival rate, 57%, was similar to that of the patients with clinical or pathological stage III disease - 58% and 54% respectively. At laparotomy 11 patients with pathological stage III disease were found to have isolated splenic involvement; their 5-year survival rate, 64%, was not appreciably different from that of the patients with clinical stage II disease, 70%; both groups were treated with radiotherapy only. From this study we can conclude that splenic involvement in Hodgkin's disease has no deleterious effect on survival and that splenic irradiation seems to be as effective as splenectomy in controlling the disease.