RT Journal Article
SR Electronic
T1 Recognition and management of neuropsychiatric complications in Parkinson's disease
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 1545
OP 1552
DO 10.1503/cmaj.060542
VO 175
IS 12
A1 Florian Ferreri
A1 Catherine Agbokou
A1 Serge Gauthier
YR 2006
UL http://www.cmaj.ca/content/175/12/1545.abstract
AB Parkinson's disease is primarily considered a motor disease characterized by rest tremor, rigidity, bradykinesia and postural disturbances. However, neuropsychiatric complications, including mood and anxiety disorders, fatigue, apathy, psychosis, cognitive impairment, dementia, sleep disorders and addictions, frequently complicate the course of the illness. The pathophysiologic features of these complications are multifaceted and include neuropathophysiologic changes of a degenerative disease, exposure to antiparkinsonian treatments and emotional reactions to having a disabling chronic illness. Changes in mental status have profound implications for the well-being of patients with Parkinson's disease and of their caregivers. Treatment is often efficacious but becomes a challenge in advanced stages of Parkinson's disease. In this article, we review the key clinical features of neuropsychiatric complications in Parkinson's disease as well as what is known about their epidemiologic characteristics, risk factors, pathophysiologic features and management.