RT Journal Article SR Electronic T1 Inappropriate use of clinical practices in Canada: a systematic review JF Canadian Medical Association Journal JO CMAJ FD Canadian Medical Association SP E279 OP E296 DO 10.1503/cmaj.211416 VO 194 IS 8 A1 Janet E. Squires A1 Danielle Cho-Young A1 Laura D. Aloisio A1 Robert Bell A1 Stephen Bornstein A1 Susan E. Brien A1 Simon Decary A1 Melissa Demery Varin A1 Mark Dobrow A1 Carole A. Estabrooks A1 Ian D. Graham A1 Megan Greenough A1 Doris Grinspun A1 Michael Hillmer A1 Tanya Horsley A1 Jiale Hu A1 Alan Katz A1 Christina Krause A1 John Lavis A1 Wendy Levinson A1 Adrian Levy A1 Michelina Mancuso A1 Steve Morgan A1 Letitia Nadalin-Penno A1 Andrew Neuner A1 Tamara Rader A1 Wilmer J. Santos A1 Gary Teare A1 Joshua Tepper A1 Amanda Vandyk A1 Michael Wilson A1 Jeremy M. Grimshaw YR 2022 UL http://www.cmaj.ca/content/194/8/E279.abstract AB Background: Inappropriate health care leads to negative patient experiences, poor health outcomes and inefficient use of resources. We aimed to conduct a systematic review of inappropriately used clinical practices in Canada.Methods: We searched multiple bibliometric databases and grey literature to identify inappropriately used clinical practices in Canada between 2007 and 2021. Two team members independently screened citations, extracted data and assessed methodological quality. Findings were synthesized in 2 categories: diagnostics and therapeutics. We reported ranges of proportions of inappropriate use for all practices. Medians and interquartile ranges (IQRs), based on the percentage of patients not receiving recommended practices (underuse) or receiving practices not recommended (overuse), were calculated. All statistics are at the study summary level.Results: We included 174 studies, representing 228 clinical practices and 28 900 762 patients. The median proportion of inappropriate care, as assessed in the studies, was 30.0% (IQR 12.0%–56.6%). Underuse (median 43.9%, IQR 23.8%–66.3%) was more frequent than overuse (median 13.6%, IQR 3.2%–30.7%). The most frequently investigated diagnostics were glycated hemoglobin (underused, range 18.0%–85.7%, n = 9) and thyroid-stimulating hormone (overused, range 3.0%–35.1%, n = 5). The most frequently investigated therapeutics were statin medications (underused, range 18.5%–71.0%, n = 6) and potentially inappropriate medications (overused, range 13.5%–97.3%, n = 9).Interpretation: We have provided a summary of inappropriately used clinical practices in Canadian health care systems. Our findings can be used to support health care professionals and quality agencies to improve patient care and safety in Canada.See related article at www.cmaj.ca/lookup/doi/10.1503/cmaj.220134