PT  - JOURNAL ARTICLE
AU  - Eugene Park, PhD
AU  - Joshua D. Bell, BSc
AU  - Andrew J. Baker MD
TI  - Traumatic brain injury: Can the consequences be stopped?
AID  - 10.1503/cmaj.080282
DP  - 2008 Apr 22
TA  - Canadian Medical Association Journal
PG  - 1163--1170
VI  - 178
IP  - 9
4099  - http://www.cmaj.ca/content/178/9/1163.short
4100  - http://www.cmaj.ca/content/178/9/1163.full
SO  - CMAJ2008 Apr 22; 178
AB  - Traumatic brain injury is a leading cause of morbidity and death in both industrialized and developing countries. To date, there is no targeted pharmacological treatment that effectively limits the progression of secondary injury. The delayed progression of deterioration of grey and white matter gives hope that a meaningful intervention can be applied in a realistic timeframe following initial trauma. In this review we discuss new insights into the subcellular mechanisms of secondary injury that have highlighted numerous potential targets for intervention.