RT Journal Article SR Electronic T1 Bordetella pertussis: the intersection of genomics and pathobiology JF Canadian Medical Association Journal JO CMAJ FD Canadian Medical Association SP 55 OP 62 DO 10.1503/cmaj.050105 VO 173 IS 1 A1 Andrew Preston YR 2005 UL http://www.cmaj.ca/content/173/1/55.abstract AB THERE HAS BEEN MUCH RECENT CONCERN over an increasing incidence of pertussis despite high levels of vaccine coverage of infants. Many reports have documented that much of the increased incidence is due to infection in adolescents and adults. This renewal of interest in pertussis comes at a time when the findings of the Bordetella genome project have led to a quantum leap forward in our understanding of the biology, evolution and pathogenesis of the bacterium responsible for the disease. The impact of this basic research on current clinical problems posed by B. pertussis infection is discussed.