RT Journal Article
SR Electronic
T1 Liver enzyme alteration: a guide for clinicians
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 367
OP 379
DO 10.1503/cmaj.1040752
VO 172
IS 3
A1 Edoardo G. Giannini
A1 Roberto Testa
A1 Vincenzo Savarino
YR 2005
UL http://www.cmaj.ca/content/172/3/367.abstract
AB ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.