RT Journal Article
SR Electronic
T1 Comparison of prognosis for men with type 2 diabetes mellitus and men with cardiovascular disease
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 40
OP 47
DO 10.1503/cmaj.071027
VO 180
IS 1
A1 Gilles R. Dagenais MD
A1 Annie St-Pierre, PhD
A1 Patrick Gilbert MD
A1 Benoît Lamarche, PhD
A1 Jean-Pierre Després, PhD
A1 Paul-Marie Bernard, MSc
A1 Peter Bogaty MD
YR 2009
UL http://www.cmaj.ca/content/180/1/40.abstract
AB Background: People with type 2 diabetes mellitus are at high risk for cardiovascular disease. In some studies, the mortality rate among people with this condition has been equivalent to that among people with cardiovascular disease. We compared cardiovascular mortality between incident cases of diabetes and cardiovascular disease. Methods: The study population was part of a random sample of 4376 men from Quebec, Canada, aged 35 to 64 years, who did not have cardiovascular disease in 1974 and who were followed until 1998. Three groups of incident cases were identified: diabetes without cardiovascular disease, first cardiovascular event (myocardial infarction, unstable angina or stroke) without diabetes, and both cardiovascular disease and diabetes. These cases were age-matched to a control group without diabetes or cardiovascular disease. Results: During the 24-year follow-up period, new diabetes without cardiovascular disease was documented in 137 men. A first cardiovascular event without diabetes was documented in 527 men. Relative to the 627 controls, men with 1 of the 2 diseases of interest had higher cardiovascular mortality (age-adjusted relative risk [RR] 3.11, 95% confidence interval [CI] 1.96–4.92) for those with diabetes and 4.46 (95% CI 3.15–6.30) for those with cardiovascular disease). However, within the first 5 years after diagnosis, men with cardiovascular disease had higher cardiovascular mortality than men with diabetes (age-adjusted RR 2.03, 95% CI 1.01–4.08). Interpretation: Men with isolated type 2 diabetes and men with isolated cardiovascular disease had similar cardiovascular mortality rates several years after initial diagnosis of either condition. These findings reinforce the need to prevent and optimally manage diabetes and cardiovascular disease.