%0 Journal Article %A Nicola Mumoli %A Marco Cei %A Roberto Incensati %A Serena Verzuri %T Multiple myeloma in a patient with fever of unknown origin and cholestasis %D 2004 %R 10.1503/cmaj.1031826 %J Canadian Medical Association Journal %P 1809-1810 %V 170 %N 12 %X THE DIFFERENTIAL DIAGNOSIS OF FEVER of unknown origin includes infectious diseases, malignancies and connective tissue diseases. Multiple myeloma is not usually included in the differential diagnosis, nor is it considered a frequent cause of cholestasis in the absence of amyloidosis. We report a case of multiple myeloma in a patient presenting with a long-standing fever and cholestasis. The patient underwent a long and unfruitful series of diagnostic procedures, including liver biopsy. The clue to the diagnosis, established with a marrow biopsy, was the presence of a paraprotein in the serum. %U https://www.cmaj.ca/content/cmaj/170/12/1809.full.pdf