RT Journal Article
SR Electronic
T1 Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 1281
OP 1284
VO 162
IS 9
A1 Michael D. Hill
A1 Philip A. Barber
A1 Jennifer Takahashi
A1 Andrew M. Demchuk
A1 Thomas E. Feasby
A1 Alastair M. Buchan
YR 2000
UL http://www.cmaj.ca/content/162/9/1281.abstract
AB Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.