@article {Hill1281, author = {Michael D. Hill and Philip A. Barber and Jennifer Takahashi and Andrew M. Demchuk and Thomas E. Feasby and Alastair M. Buchan}, title = {Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke}, volume = {162}, number = {9}, pages = {1281--1284}, year = {2000}, publisher = {CMAJ}, abstract = {Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9\%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.}, issn = {0820-3946}, URL = {https://www.cmaj.ca/content/162/9/1281}, eprint = {https://www.cmaj.ca/content/162/9/1281.full.pdf}, journal = {CMAJ} }