RT Journal Article
SR Electronic
T1 Nonsteroidal anti-inflammatory drugs for the prevention of colon cancer
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 595
OP 602
VO 149
IS 5
A1 D. Turner
A1 H. J. Berkel
YR 1993
UL http://www.cmaj.ca/content/149/5/595.abstract
AB OBJECTIVE: To summarize the results of animal and human studies of the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on neoplastic growth in the colon and to outline the possible mechanisms involved. DATA SOURCES: Research articles published in English before June 1992 were identified from MEDLINE. STUDY SELECTION: Nine articles on the polyp-cancer sequence were reviewed, 8 on the apparent pathophysiologic aspects of tumour inhibition by NSAIDs and 22 on animal and human research into the effect of NSAIDs on colon carcinogenesis. RESULTS: The results of animal and human research into the anticarcinogenic effect of NSAIDs suggest that the drugs are effective in preventing tumour growth in the colon. CONCLUSIONS: Intervention studies in humans are necessary to elucidate the therapeutic possibilities of NSAIDs, particularly in populations at increased risk for the development of colon cancer.