TY - JOUR T1 - Nonsteroidal anti-inflammatory drugs for the prevention of colon cancer JF - Canadian Medical Association Journal JO - CMAJ SP - 595 LP - 602 VL - 149 IS - 5 AU - D. Turner AU - H. J. Berkel Y1 - 1993/09/01 UR - http://www.cmaj.ca/content/149/5/595.abstract N2 - OBJECTIVE: To summarize the results of animal and human studies of the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on neoplastic growth in the colon and to outline the possible mechanisms involved. DATA SOURCES: Research articles published in English before June 1992 were identified from MEDLINE. STUDY SELECTION: Nine articles on the polyp-cancer sequence were reviewed, 8 on the apparent pathophysiologic aspects of tumour inhibition by NSAIDs and 22 on animal and human research into the effect of NSAIDs on colon carcinogenesis. RESULTS: The results of animal and human research into the anticarcinogenic effect of NSAIDs suggest that the drugs are effective in preventing tumour growth in the colon. CONCLUSIONS: Intervention studies in humans are necessary to elucidate the therapeutic possibilities of NSAIDs, particularly in populations at increased risk for the development of colon cancer. ER -