RT Journal Article
SR Electronic
T1 Hypertension, hypokalemia, hyporeninemia and severe target organ damage
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 241
OP 243
VO 114
IS 3
A1 G. E. Wilkins
YR 1976
UL http://www.cmaj.ca/content/114/3/241.abstract
AB A 51-year-old woman with a 20-year history of severe hypertension and target organ damage had nondiuretic hypokalemia, kaluresis, suppressed plasma renin activity and elevated urinary excretion of aldosterone. Renal arteriography demonstrated unilateral renal artery stenosis secondary to fibromuscular hyperplasia. Blood pressure responded only minimally to almost all antihypertensive agents. Spironolactone, 300 to 400 mg/d, produced distinct improvement in blood pressure, which was maintained for 13 months.