RT Journal Article
SR Electronic
T1 Alcohol and acetaldehyde metabolism in Caucasians, Chinese and Amerinds
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 851
OP 855
VO 115
IS 9
A1 Reed, T. E.
A1 Kalant, H.
A1 Gibbins, R. J.
A1 Kapur, B. M.
A1 Rankin, J. G.
YR 1976
UL http://www.cmaj.ca/content/115/9/851.abstract
AB Ethanol (0.4 to 0.8 g/kg in 30 minutes) was given by mouth to 102 healthy young volunteers (37 Caucasian men, 21 Caucasian women, 20 Chinese men and 24 Ojibwa men). Venous blood concentrations of ethanol and acetaldehyde 60, 90, 120 and 150 minutes after the end of drinking were measured by gas chromatography. The calculated rates of ethanol metabolism in the Caucasian men and women did not differ, but the overall group means for subgroups of Caucasians (103.6 mg/kg-h), Chinese (136.6 mg/kg-h) and Ojibwa (182.7 mg/kg-h) with decreasing postabsorption values differed significantly from each other. Mean acetaldehyde values paralleled the rates of ethanol metabolism: Ojibwa, 14.6 mug/ml; Chinese, 10.0 mug/ml; and Caucasians, 9.4 mug/ml. The high rate of ethanol metabolism in Amerind subjects differs from previous findings. Habitual level of alcohol consumption, proportion of body fat and genetic factors appear to account for most of the group differences.