RT Journal Article SR Electronic T1 Familial infantile cortical hyperostosis in a large Canadian family JF Canadian Medical Association Journal JO CMAJ FD Canadian Medical Association SP 1172 OP 1174 VO 130 IS 9 A1 A. K. Maclachlan A1 J. W. Gerrard A1 C. S. Houston A1 E. J. Ives YR 1984 UL http://www.cmaj.ca/content/130/9/1172.abstract AB Infantile cortical hyperostosis is a rare proliferative bone disease affecting infants under the age of 6 months. In 1961 a large family of French-Canadian origin in which 14 children in three generations were affected was described. Since then 20 new cases have been found in this family. This is the largest familial aggregation of this disease reported in the literature to date. On the basis of the findings in this pedigree, the familial form of the disease appears to be transmitted by a single autosomal dominant gene with incomplete penetrance and variable expressivity.