PT  - JOURNAL ARTICLE
AU  - K. J. Clementi
TI  - Treatment of salmonella carriers with trimethoprim-sulfamethoxazole
DP  - 1975 Jun 14
TA  - Canadian Medical Association Journal
PG  - 28--32
VI  - 112
IP  - 13
4099  - http://www.cmaj.ca/content/112/13/28.short
4100  - http://www.cmaj.ca/content/112/13/28.full
SO  - CMAJ1975 Jun 14; 112
AB  - One hundred and two patients with salmonellosis were observed, as either acute cases or asymptomatic carriers, over a span of 6 years. Twenty-eight patients were treated with antibiotics only or received no treatment; those in the treated group became negative for the infecting organisms after a mean time of 160 days, as compared with a mean of 52.4 days for those who were not treated. Seventy-four other patients were treated with frimthoprim-sulfamethoxazole (TMP-SMX) as the sole medication or after prior antibiotic therapy. Sixty of these patients (81.1%) were free from Salmonella in the mean time of 19.2 days, whereas 14 failed to respond and the condition cleared spontaneously in a mean time of 134.9 days. The poor response to treatment with TMP-SMX by children 2 years of age and younger is noted. The beneficial effects of treatment with TMP-SMX, as compared with antibiotics or no treatment at all, are examined in the light of the need to protect the public from this potentially dangerous infection.