RT Journal Article
SR Electronic
T1 Cimetidine-resistant Zollinger-Ellison syndrome: successful management with ranitidine
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 256
OP 258
VO 129
IS 3
A1 F. M. Habal
A1 S. J. Soldin
A1 G. R. Greenberg
YR 1983
UL http://www.cmaj.ca/content/129/3/256.abstract
AB In a patient with the Zollinger-Ellison syndrome who had undergone vagotomy, pyloroplasty and, later, gastrojejunostomy, epigastric pain and stomal ulceration recurred despite the use of high doses (2700 mg/d) of cimetidine. Ranitidine, a new histamine H2-receptor antagonist, reversed all symptoms and healed the stomal ulcer without side effects, thus obviating the need for further surgery. Ranitidine may prove to be the drug of choice in the medical management of patients with the Zollinger-Ellison syndrome.