TY - JOUR T1 - Cimetidine-resistant Zollinger-Ellison syndrome: successful management with ranitidine JF - Canadian Medical Association Journal JO - CMAJ SP - 256 LP - 258 VL - 129 IS - 3 AU - F. M. Habal AU - S. J. Soldin AU - G. R. Greenberg Y1 - 1983/08/01 UR - http://www.cmaj.ca/content/129/3/256.abstract N2 - In a patient with the Zollinger-Ellison syndrome who had undergone vagotomy, pyloroplasty and, later, gastrojejunostomy, epigastric pain and stomal ulceration recurred despite the use of high doses (2700 mg/d) of cimetidine. Ranitidine, a new histamine H2-receptor antagonist, reversed all symptoms and healed the stomal ulcer without side effects, thus obviating the need for further surgery. Ranitidine may prove to be the drug of choice in the medical management of patients with the Zollinger-Ellison syndrome. ER -