RT Journal Article
SR Electronic
T1 Rh immunization in Manitoba: progress in prevention and management
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 343
OP 345
VO 129
IS 4
A1 Bowman, J. M.
A1 Pollock, J.
YR 1983
UL http://www.cmaj.ca/content/129/4/343.abstract
AB For two decades the perinatal mortality caused by erythroblastosis has been decreasing in Manitoba. The improved management of Rh-immunized pregnancies has lowered the death rate among affected infants from 10.8% to 3.4%, while the prevention of Rh immunization has reduced its incidence from 9.1 to 2.2 per 1000 total births. In its first 6 years and 8 months Manitoba's antenatal prophylaxis program, in which immunoglobulin is administered to Rh-negative women at 28 weeks' gestation, reduced the incidence of Rh immunization during pregnancy by 93%. In combination with post-abortion and postpartum prophylaxis the antenatal treatment has provided a protection rate of 98.6% among primigravidas at risk. Further improvements are expected.