RT Journal Article
SR Electronic
T1 Amantadine-dyazide interaction
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 974
OP 975
VO 129
IS 9
A1 T. W. Wilson
A1 A. H. Rajput
YR 1983
UL http://www.cmaj.ca/content/129/9/974.abstract
AB To document an interaction between amantadine hydrochloride and Dyazide that had apparently produced amantadine toxicity, a patient was given amantadine alone for 1 week, followed by amantadine plus Dyazide for another week, under controlled conditions. A diuretic effect was observed after Dyazide was added to the regimen, but the urine amantadine excretion fell, and the drug's plasma concentration increased. It was concluded that one or both of the components of Dyazide (hydrochlorothiazide and triamterene) reduce the clearance of amantadine and can produce higher plasma concentrations and toxic effects.