RT Journal Article
SR Electronic
T1 Anaphylaxis due to thiopental sodium anesthesia
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 292
OP 294
VO 123
IS 4
A1 Dolovich, J.
A1 Evans, S.
A1 Rosenbloom, D.
A1 Goodacre, R.
A1 Rafajac, F. O.
YR 1980
UL http://www.cmaj.ca/content/123/4/292.abstract
AB Anaphylaxis due to an anesthetic is one type of cardiovascular emergency that can occur during general anesthesia. Anaphylactic reactions to muscle relaxants have been documented. Barbiturates, used as sedatives, are well known to produce cutaneous reactions, but anaphylaxis after their ingestion seems to be rare. Generalized allergic reactions to thiopental sodium during anesthesia are mentioned in the product monograph for Penthothal sodium, and rare case reports of anaphylactic reactions to infused thiopental have appeared, generally in the anesthesiology literature. Documentation of the immunologic responses to thiopental sodium has been limited to the demonstration of an allergic reaction to thiopental by skin testing in some cases. This report describes a woman who, after having tolerated thiopental sodium and other general anesthetics, became sensitive to this agent and had a severe acute reaction at the time of induction of general anesthesia.