RT Journal Article
SR Electronic
T1 Treatment of refractory congestive heart failure and normokalemic hypochloremic alkalosis with acetazolamide and spironolactone
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 883
OP 887
VO 123
IS 9
A1 M. I. Khan
YR 1980
UL http://www.cmaj.ca/content/123/9/883.abstract
AB Combination therapy with a loop diuretic and an aldosterone antagonist can produce normokalemic hypochloremic alkalosis, a complication not previously documented in the literature. This report describes 74 patients who had severe congestive heart failure treated with a combination of furosemide and spironolactone in whom this complication developed. Acetazolamide corrected the metabolic abnormality. The combination of furosemide and spironolactone with intermittent courses of acetazolamide was very effective in the treatment of severe congestive heart failure complicated by normokalemic hypochloremic alkalosis.