RT Journal Article
SR Electronic
T1 Estradiol receptor levels in human breast carcinomas
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 1010
OP 1012
VO 124
IS 8
A1 C. E. Bird
A1 B. Houghton
A1 W. Westenbrink
A1 M. Tenniswood
A1 E. E. Sterns
A1 A. F. Clark
YR 1981
UL http://www.cmaj.ca/content/124/8/1010.abstract
AB The presence or absence of a specific estradiol-binding protein receptor in the cytoplasm of primary and secondary tumour cells has been used by physicians as an important guide in deciding whether to use hormonal therapy for patients with metastatic breast cancer. This report gives the levels of estradiol receptors in the cytosol of 228 primary and secondary breast tumours, measured by a sensitive multiple-point assay in which dextran-coated charcoal separated bound form unbound estrogen. The data were analysed with a Scatchard plot. Of the 175 primary and 53 secondary tumours 53% and 32% respectively gave positive results. The mean receptor level in the primary tumours was significantly higher among older patients and increased with age. With metastatic lesions positive results were more common in lymph node samples tha in skin nodule samples.