PT  - JOURNAL ARTICLE
AU  - C. E. Bird
AU  - B. Houghton
AU  - W. Westenbrink
AU  - M. Tenniswood
AU  - E. E. Sterns
AU  - A. F. Clark
TI  - Estradiol receptor levels in human breast carcinomas
DP  - 1981 Apr 15
TA  - Canadian Medical Association Journal
PG  - 1010--1012
VI  - 124
IP  - 8
4099  - http://www.cmaj.ca/content/124/8/1010.short
4100  - http://www.cmaj.ca/content/124/8/1010.full
SO  - CMAJ1981 Apr 15; 124
AB  - The presence or absence of a specific estradiol-binding protein receptor in the cytoplasm of primary and secondary tumour cells has been used by physicians as an important guide in deciding whether to use hormonal therapy for patients with metastatic breast cancer. This report gives the levels of estradiol receptors in the cytosol of 228 primary and secondary breast tumours, measured by a sensitive multiple-point assay in which dextran-coated charcoal separated bound form unbound estrogen. The data were analysed with a Scatchard plot. Of the 175 primary and 53 secondary tumours 53% and 32% respectively gave positive results. The mean receptor level in the primary tumours was significantly higher among older patients and increased with age. With metastatic lesions positive results were more common in lymph node samples tha in skin nodule samples.