PT  - JOURNAL ARTICLE
AU  - P. Rollin
AU  - A. J. Antaki
TI  - [Poisoning due to tricyclic antidepressants in children and adolescents]
DP  - 1979 Apr 21
TA  - Canadian Medical Association Journal
PG  - 951--956
VI  - 120
IP  - 8
4099  - http://www.cmaj.ca/content/120/8/951.short
4100  - http://www.cmaj.ca/content/120/8/951.full
SO  - CMAJ1979 Apr 21; 120
AB  - During the last decade there has been a substantial increase in the number of poisonings due to tricyclic antidepressants in both children and adults. The main toxic manifestations are of anticholinergic origin, and the most frequent constitute the so-called central anticholinergic syndrome. Most of the deaths result from the cardiac complications. Three cases are presented that illustrate chiefly the toxic manifestations related to the central nervous system. The therapeutic management is reviewed in the light of the metabolism of the tricyclic antidepressants, their pharmacologic action and the mechanism of their toxic effects.