RT Journal Article
SR Electronic
T1 Influence of age and previous use of diazepam dosage required for endoscopy
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 513
OP 514
VO 118
IS 5
A1 H. G. Giles
A1 S. M. MacLeod
A1 J. R. Wright
A1 E. M. Sellers
YR 1978
UL http://www.cmaj.ca/content/118/5/513.abstract
AB In 19 patients (10 men and 9 women) a 22-fold variation was observed in the intravenous dose of diazepam necessary as preparation for endoscopy (median dose, 20 mg; range, 5 to 110 mg). Analysis of plasma samples for diazepam and N-desmethyldiazepam revealed that the clinical response did not relate to the rate or character of initial drug distribution. There was a high correlation (r = 0.96) between the dose and the plasma concentration 10 minutes after administration. Users of diazepam displayed tolerance to its pharmacologic effects, requiring a significantly larger (P less than 0.05) dose than nonusers (median doses, 35.0 mg and 14.5 mg respectively). Older patients required less than younger patients (r = -0.54, P less than 0.05). The variation between individuals in the dose of diazepam required as preparation for endoscopy cannot be explained by variation in drug disposition but instead reflects previous diazepam use, age and probably differences in sensitivity at the site or sites of drug action.