TY - JOUR T1 - Alpha1-antitrypsin phenotypes and lung function in a moderately polluted northern Ontario community JF - Canadian Medical Association Journal JO - CMAJ SP - 669 LP - 672 VL - 118 IS - 6 AU - D. N. Ostrow AU - J. Manfreda AU - T. Dorman AU - R. M. Cherniack Y1 - 1978/03/18 UR - http://www.cmaj.ca/content/118/6/669.abstract N2 - To determine whether persons with intermediate value alpha1-antitrypsin phenotypes living in a polluted environment manifest significant abnormalities in lung function, a study was undertaken of an age-, sex- and smoking-stratified sample of 391 persons from the town of Fort Frances, Ont., which has elevated values of total dustfall, suspended particulates and hydrogen sulfide. Indices of pulmonary function were derived from the maximum expiratory flow and the single breath expiratory flow and the single breath expiratory nitrogen washout curves. The percentage frequency of the M, MS and MZ pheontypes was 91.7, 7.3 and 0.8, respectively. There was no significant difference between the M and MS groups as indicated by the nitrogen washout curve and maximum expiratory flow curve. There was no significant difference between the three MZ subjects and the M group. In both M and MS groups smokers displayed evidence of airflow obstruction when compared with nonsmokers. It would appear that, when compared with M subjects, persons with the MS phenotype living in a moderately polluted area show no changes in indicators of pulmonary function, including tests of early airway disease, that cannot be attributed to their smoking habit. ER -