PT  - JOURNAL ARTICLE
AU  - M. C. Champion
AU  - M. Hartnett
AU  - M. Yen
TI  - Domperidone, a new dopamine antagonist
DP  - 1986 Sep 01
TA  - Canadian Medical Association Journal
PG  - 457--461
VI  - 135
IP  - 5
4099  - http://www.cmaj.ca/content/135/5/457.short
4100  - http://www.cmaj.ca/content/135/5/457.full
SO  - CMAJ1986 Sep 01; 135
AB  - Domperidone is a dopamine antagonist that has recently been released in Canada. Unlike metoclopramide hydrochloride, the other available dopamine antagonist, it does not readily enter the central nervous system. Domperidone acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported. Domperidone has been approved for use in Canada for the symptomatic management of upper gastrointestinal tract motility disorders and to prevent gastrointestinal symptoms associated with the use of dopamine agonist agents in Parkinson's disease. The pharmacologic features, indications and side effects of domperidone are reviewed.